Immune Reactivity to Wheat, Gluten, and Their Processed Protein Forms
What this profile measures
Antigens tested (IgG and IgA measured separately for each antigen)
WheatBurden™ evaluates IgG and IgA antibodies against a comprehensive set of wheat, gluten, and enzyme targets. Idenitfy immune reactivity across wheat components, gluten peptides, and cross-reactive enzyme markers.
Antigens List
Full Wheat Kernel
Wheat
Wheat Germ Agglutinin
Non-Gluten Wheat Proteins
Non-Gluten Proteins - A
Non-Gluten Proteins - B
Gluten Family Peptides
Gliadin Toxic Peptides
Native + Deamidated Alpha-Gliadin-33-mer
Alpha-Gliadin-17-mer
Gamma-Gliadin-15-mer
Omega-Gliadin-17-mer
Glutenin-21-mer
Gluteomorphin + Prodynorphin
Gliadin Transglutaminase
Gliadin-Transglutaminase Complex
Transglutaminase
Microbial Transglutaminase
Transglutaminase-2
Transglutaminase-3
Transglutaminase-6
Cooked/Processed Wheat Products
White Flour Dough
Whole Wheat Bread (Yeast-Free)
Sprouted Whole Wheat Bread
Wheat Tortilla Bread (Yeast-Free)
American Sourdough Bread
Italian Wheat Bread
Italian Pasta (Cooked)
 
When to use WheatBurden™
Use WheatBurden™ when you suspect wheat/gluten may be contributing to chronic symptoms involving the gut, nervous system, or skin—yet standard celiac labs are negative, incomplete, or do not fully explain the patient's clinical presentation.
Persistent GI complaints where basic dietary elimination has not resolved symptoms.
Suspected Celiac disease, non-celiac gluten sensitivity, dermatitis herpetiformis, gluten ataxia, or other wheat/gluten-related disorders.
Autoimmune risk or family history where wheat- related autoimmunity could be an upstream driver.
Non-responsive GI symptoms in patients already following a gluten-reduced or gluten-free diet.
Multiple symptom complaints (e.g., Chronic Fatigue Syndrome, Fibromyalgia) where food opioids and wheat reactivity may contribute to systemic burden.
Depression, cognitive changes, or neuro-autoimmunity where gluten involvement is suspected.