Immune Reactivity to Wheat, Gluten, and Their Processed Protein Forms

What this profile measures

Antigens tested (IgG and IgA measured separately for each antigen)

WheatBurden™ evaluates IgG and IgA antibodies against a comprehensive set of wheat, gluten, and enzyme targets. Idenitfy immune reactivity across wheat components, gluten peptides, and cross-reactive enzyme markers.

Antigens List

Full Wheat Kernel

• Wheat

• Wheat Germ Agglutinin

Non-Gluten Wheat Proteins

• Non-Gluten Proteins - A

• Non-Gluten Proteins - B

Gluten Family Peptides

• Gliadin Toxic Peptides

• Native + Deamidated Alpha-Gliadin-33-mer

• Alpha-Gliadin-17-mer

• Gamma-Gliadin-15-mer

• Omega-Gliadin-17-mer

• Glutenin-21-mer

• Gluteomorphin + Prodynorphin

Gliadin Transglutaminase

• Gliadin-Transglutaminase Complex

Transglutaminase

• Microbial Transglutaminase

• Transglutaminase-2

• Transglutaminase-3

• Transglutaminase-6

Cooked/Processed Wheat Products

• White Flour Dough

• Whole Wheat Bread (Yeast-Free)

• Sprouted Whole Wheat Bread

• Wheat Tortilla Bread (Yeast-Free)

• American Sourdough Bread

• Italian Wheat Bread

• Italian Pasta (Cooked)

When to use WheatBurden™

Use WheatBurden™ when you suspect wheat/gluten may be contributing to chronic symptoms involving the gut, nervous system, or skin—yet standard celiac labs are negative, incomplete, or do not fully explain the patient's clinical presentation.

• Persistent GI complaints where basic dietary elimination has not resolved symptoms.

• Suspected Celiac disease, non-celiac gluten sensitivity, dermatitis herpetiformis, gluten ataxia, or other wheat/gluten-related disorders.

• Autoimmune risk or family history where wheat- related autoimmunity could be an upstream driver.

• Non-responsive GI symptoms in patients already following a gluten-reduced or gluten-free diet.

• Multiple symptom complaints (e.g., Chronic Fatigue Syndrome, Fibromyalgia) where food opioids and wheat reactivity may contribute to systemic burden.

• Depression, cognitive changes, or neuro-autoimmunity where gluten involvement is suspected.